Group Leader
Molecular and Cellular Modeling Group
Heidelberg Institute for Theoretical Studies
Professor “Computational Structural Biology”
Center for Molecular Biology (ZMBH)
Heidelberg University
SCIENTIFIC VITA
| 1982 – 1985 | B.A. Hons. Physics University of Oxford, UK |
| 1985 – 1988 | D.Phil. Molecular Biophysics University of Oxford, UK |
| 1988 – 1991 | Postdoc Department of Chemistry University of Houston, USA |
| 1992 – 2001 | Group Leader Structural and Computational Biology Programme European Molecular Biology Laboratory (EMBL), Heidelberg |
| 2001 – 2003 | Adjunct Professor, International University in Germany, Bruchsal |
| Since 2001 | Group Leader Molecular and Cellular Modeling Group Heidelberg Institute for Theoretical Studies (HITS) |
| Since 2012 | W3-Professor “Computational Structural Biology” Center for Molecular Biology (ZMBH) Heidelberg University |
| 2015 – 2016 | Scientific Director Heidelberg Institute for Theoretical Studies (HITS) |
AWARDS
| 2004 | Hansch Award of the International QSAR and Modeling Society |
| 2016 | International Society of Quantum Biology and Pharmacology (ISQBP) Award in Computational Biology |
SCIENTIFIC COORDINATION
| 1994 – 1996 | Coordinator, EU Biotechnology Programme Project, “Cytochrome P450- ligand interactions” |
| Since 2013 | Scientific Advisory Council Leibniz-Institute for Molecular Pharmacology (FMP), Berlin-Buch |
| Since 2015 | Scientific Advisory Board Max Planck Institute of Biophysics, Frankfurt |
PATENTS
2013 “Uso di inhibitori della Pteridina Reduttasi per la prevenzione e/o il trattamento di infezioni parassitarie”, Italian Patent Nr. 1403584, Costi MP, Luciani R, Nerini E, Guerrieri D, Ferrari S, Venturelli A, Lazzari S, (Univ. Modena); Wade R, Henrich S, Motiejunas D. (HITS)
2014 “Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer” United States Patent No.: US 8,916,679 B2. Costi MP, Marverti G, Cardinale D, Venturelli A, Ferrari S, Ponterini G (Univ. Modena), Henrich S, Salo-Ahen O, Wade R. (HITS)
RELEVANT PUBLICATIONS
Amaral M. Kokh DB, Bomke, J, Wegener A, Buchstaller HP, Eggenweiler HM, Matias P, Sirrenberg C, Wade RC, Frech M. Protein conformational flexibility modulates kinetics and thermodynamics of drug binding Nature Commun. 8 (2017): 2276
Salo-Ahen, OMH, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC. Hotspots in an Obligate Homodimeric Anticancer Target. Structural and Functional Effects of Interfacial Mutations in Human Thymidylate Synthase J. Med. Chem., 58 (2015), 3572–3581
Stank A., Kokh DB, Horn M, Sizikova E, Neil R, Panecka J, Richter S, Wade, R.C. TRAPP webserver: predicting protein binding site flexibility and detecting transient binding pockets..Nucleic Acids Res (2017) gkx277
Martinez, M., Bruce, N.J., Romanowska, J., Kokh, D.B., Ozboyaci, M., Yu, X., Öztürk, M.A., Richter, S. and Wade, R.C. SDA 7: A modular and parallel implementation of the simulation of diffusional association software. J. Comput. Chem., (2015) 36:1631-1645.
Cardinale, D., Guaitoli, G., Tondi, D., Luciani, R., Henrich, S., Salo-Ahen, O. M. H., Ferrari, S., Marverti, G., Guerrieri, D., Ligabue, A., Frassineti, C., Pozzi, C., Mangani, S., Fessas, D., Guerrini, R., Ponterini, G., Wade, R.C. and Costi, M.P. Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase Proc. Natl. Acad. Sci. USA (2011) 108, 13889-13890, E542-E549.