Deputy Medical Director, Department of Cardiology, Angiology, Pneumology
University Hospital Heidelberg
Head Genomic Research & Institute for Cardiomyopathies Heidelberg
University Hospital Heidelberg
W3-Professor “Precision Digital Health”
SCIENTIFIC VITA
| 1998 – 2005 | Medical School, Albert-Ludwigs-University of Freiburg |
| 2001 – 2004 | Research Doctorate, Department of Cardiology, University Hospital of Freiburg |
| 2003 – 2004 | Scientific Assistant, Laboratory of Engineering & Bioinformatics, Perfusion Technologies GmbH |
| 2005 – 2009 | Research Fellow, Heidelberg University |
| Since 2009 | Research Group Leader, Laboratory of Molecular Genetics and Translational Biotechnology, Heidelberg |
| Since 2011 | Head of Genomic Research, Department of Internal Medicine III, University Hospital Heidelberg |
| Since 2015 | Head Institute for Cardiomyopathies Heidelberg (ICH.) |
| Since 2018 | Stanford University School of Medicine, Genome Technology Center, California, USA – Visiting Associate Professor of Genetics |
| Since 2018 | Deputy Medical Director, Department of Cardiology, Angiology, Pneumology University Hospital Heidelberg |
| Since 2022 | W3 Professor “Precision Digital Health” |
AWARDS
| 2001 – 2005 | E-Fellows Scholarship, Munich, Germany |
| 2003 – 2005 | Scholarship of Bayer Foundations, Leverkusen, Germany |
| 2009 | Best Poster Award, 7th Dutch-German Meeting of the Molecular Cardiology Groups |
| 2010 | Wilhelm P. Winterstein Science Award of the German Heart Foundation |
| 2009 – 2011 | Research fellowship Young Investigator Award of the Medical Faculty Heidelberg |
| 2017 | Wilhelm P. Winterstein Science Award of the German Heart Foundation |
| 2017 | European Society of Cardiology “primus inter pares” |
SCIENTIFIC COORDINATION
| 2001 – 2013 | Coordinator of the Innovation Alliance Subgenome Fractionation for High-throughput Sequencing, Germany |
| Since 2013 | Coordinator Cardiomyopathy Group DZHK Registries, Germany |
| Since 2013 | Steering Committee of the Network for Congenital Heart Diseases, Germany |
| Since 2015 | Coordinator Cardiomyopathy Research Board |
| Since 2018 | Co-Coordinator “Informatics for Life” |
| Since 2022 | Coordinator “AG Kardiomyopathien”, German Society of Cardiology |
PATENTS
US Patent 9,938,580 Epigenetic signatures as marker for cardiomyopathies and myocardial insufficiencies (Granted April 10, 2018). US Patent 9,611,511 Complex miRNA sets as novel biomarkers for an acute coronary syndrome (Granted April 4, 2017). EP 10 004 190.4 Complex miRNA sets as novel biomarkers for an acute coronary syndrome; EP 11715666.1 Complex miRNA sets as novel biomarkers for an acute coronary syndrome; EP 101 851 36.8 Complex miRNS sets as novel biomarkers for an acute coronary syndrome; EP 11169192.9 MicroRNA signatures als Biomarker für die dilatative Kardiomypathie (DCM) und Herzinsuffizienz; PCT/EP2012/060927 Complex set of miRNAs as noninvasive biomarkers for dilated cardiomyopathy; EP12163180.8 Complex sets of miRNAs as non-invasive biomarkers for early diagnosis of acute myocardial infarction; PCT/EP2013/057118 Complex sets of miRNAs as non-invasive biomarkers for early diagnosis of acute myocardial infarction; EP 13168684.2 MICRORNA AS NON-INVASIVE BIOMARKERS FOR HEART FAILURE
RELEVANT PUBLICATIONS
Haas J, Mester S, Lai A, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Rausch T, Nietsch R, Boeckel JN, Carstensen A, Völkers M, Dietrich C, Pils D, Amr A, Holzer DB, Martins Bordalo D, Oehler D, Weis T, Mereles D, Buss S, Riechert E, Wirsz E, Wuerstle M, Korbel JO, Keller A, Katus HA, Posch AE, Meder B. Genomic structural variations lead to dysregulation of important coding and non-coding RNA species in dilated cardiomyopathy. EMBO Mol Med. 2017 Nov 14. pii: e201707838.
Sedaghat-Hamedani F, Haas J, Zhu F, Geier C, Kayvanpour E, Liss M, Lai A, Frese K, Pribe-Wolferts R, Amr A, Li DT, Samani OS, Carstensen A, Bordalo DM, Müller M, Fischer C, Shao J, Wang J, Nie M, Yuan L, Haßfeld S, Schwartz C, Zhou M, Zhou Z, Shu Y, Wang M, Huang K, Zeng Q, Cheng L, Fehlmann T, Ehlermann P, Keller A, Dieterich C, Streckfuß-Bömeke K, Liao Y, Gotthardt M, Katus HA, Meder B. Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy. Eur Heart J. 2017 Oct 6. doi: 10.1093/eurheartj/ehx545.
Meder B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Frese K, Lai A, Nietsch R, Scheiner C, Mester S, Martins Bordalo D, Amr A, Dietrich C, Pils D, Siede D, Hund H, Bauer AS, Holzer DB, Ruhparwar A, Mueller-Hennessen M, Weichenhan D, Plass C, Weis TM, Backs J, Wuerstle ML, Keller A, Katus HA, Posch AE. Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and A Novel Class of Biomarkers for Heart Failure. Circulation. 2017 Aug 24. doi: 10.1161/CIRCULATIONAHA.117.027355.
Amr A, Kayvanpour E, Sedaghat-Hamedani F, Passerini T, Mihalef V, Lai A, Neumann D, Georgescu B, Buss S, Mereles D, Zitron E, Posch AE, Würstle M, Mansi T, Katus HA, Meder B. Personalized Computer Simulation of Diastolic Function in Heart Failure. Genomics Proteomics Bioinformatics. 2016 Aug;14(4):244-52. doi: 10.1016/j.gpb.2016.04.006.
Kayvanpour E, Mansi T, Sedaghat-Hamedani F, Amr A, Neumann D, Georgescu B, Seegerer P, Kamen A, Haas J, Frese KS, Irawati M, Wirsz E, King V, Buss S, Mereles D, Zitron E, Keller A6, Katus HA, Comaniciu D, Meder B. Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart. PLoS One. 2015 Jul 31;10(7):e0134869. doi: 10.1371/journal.pone.0134869.