Prof. Dr. med. Raffaele De Simone

Professor of Cardiac Surgery
University of Heidelberg



1978 – 1985 Medical Education
University of Naples, Italy
1985 – 1988 Research Fellow, Department of Cardiology, University of Naples, Italy
1988 – 1989 Resident in Cardiology, Department of Cardiology,
University Hospital Heidelberg
1989 Italian Board of Cardiology
1989 – 1995 Resident in Cardiac Surgery
Department of Cardiac Surgery,
University of Heidelberg
1992 PhD University of Naples, Italy
2003 German Board of Cardiac Surgery
2004 German Board of Medical Informatics
2008 – 2015 Programme Director off-pump coronary artery bypass and cardiac arrhythmia surgery,
University Hospital Heidelberg
2006 – 2015 Director of Collaborative Research Centre SFB/TR 125 Cognition Guided Surgery, Project B01.
Since 2006 Professor of Cardiac Surgery
University Hospital Heidelberg



1991 Research Prize of the “European Society of Cardiology”
1993 Best Presentation Award at GCR Heart, Rome
1999 St. Jude Medical Prize
at the 28th Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery
2006 Ethicon-Prize
at the 35th Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery



2006 – 2009 EACTS Information Officer
2006 – 2009 Council Member of European Association for Cardio-Thoracic Surgery (EACTS)
2006 – 2010 Board of Directors des „Cardiothoracic Surgery Network“ (CTSNet)
2010 Board of Directors of „Cardiothoracic Surgery Network“ (CTSNet)



De Simone, R., Glombitza, G., Vahl, C.F., Albers J., Meinzer H-P., Hagl, S., 1999. „Three-dimensional color doppler: a clinical study in patients with mitral regurgitation” In: Journal of the American College of Cardiology. 33(6), 1646-1654

Engelhardt, S., De Simone, R., Full, P.M., Karck, M., Wolf, I. (2018). “Improving Surgical Training Phantoms by Hyperrealism: Deep Unpaired Image-to-Image Translation from Real Surgeries”. 21st conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), 2018.

Engelhardt, S., Wolf, I., Al-Maisary, S., Schmidt, H., Meinzer, H.-P., Karck, M., De Simone, R., 2016. „Intraoperative Quantitative Mitral Valve Analysis Using Optical Tracking Technology.” In: The Annals of Thoracic Surgery 101(5): 1950–1956.

Engelhardt, S., De Simone, R., Al-Maisary, S., Kolb, S., Karck, M., Meinzer, H.-P., Wolf, I., 2016. “Accuracy evaluation of a mitral valve surgery assistance system based on optical tracking.” In: International Journal of Computer Assisted Radiology and Surgery 11(10), 1891–1904.

Engelhardt, S., Lichtenberg, N., Al-Maisary, S., De Simone, R., Rauch, H., Roggenbach, J., Müller, S., Karck, M., Meinzer, H.-P., Wolf, I., 2015. “Towards Automatic Assessment of the Mitral Valve Coaptation Zone from 4D Ultrasound.” In: Functional Imaging and Modeling of the Heart, Lecture Notes in Computer Science. Springer International Publishing, pp. 137–145.