Prof. Dr. med. Patrick Most


Head of Molecular and Translational Cardiology Division
W3-Professor for Molecular and Translational Cardiology
University Hospital Heidelberg



1991 – 1998 Study of Medicine
University of Heidelberg and
University of Lübeck
1998 – 1999 Medical Internship
University Hospital Lübeck
1999 Full License to Practice Medicine (Approbation)
1999 – 2002 Resident
Department of Cardiology, Angiology and Pulmonology, University Hospital Lübeck
2002 Medical Doctorate Degree (summa cum laude)
2002 – 2006 Resident
Department of Cardiology, Angiology and Pulmonology, University Hospital Heidelberg
2003 – 2004 Post-Doctorate Training
Center  for  Translational Medicine,
Thomas Jefferson University, Philadelphia, USA
2006 – 2010 Assistant Professor  and  Faculty Member
Medical College and Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, USA
2009 Board Certification
Since 2010 W3-Professor for Molecular  and  Translational  Cardiology
Medical College and University Hospital Heidelberg
Since 2010 Adjunct Associate Professor
Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA



2013 – 2014 Co-founder and Chief Executive Officer of the Biotech Startup InoCard GmbH
2014 – 2017 Managing Director of uniQure GmbH Germany (successor to InoCard GmbH and German affiliation of uniQure NV, Amsterdam, Netherlands)
2015 – 2017 Member of the uniQure NV Leadershipteam and Senior Vice President Cardiovascular Therapeutic Area



2001 German Society of Cardiology (DGK), of the Oskar Lapp Foundation Science Award
2001 Trainee Award
Council on Basic Cardiovascular Sciences of the American Heart Association (AHA)
2002 Early Career Development Award
Council on  Basic  Cardiovascular  Sciences  of  the American Heart Association (AHA)
2004 Young Investigator Award of the German Society for Internal Medicine (GDIM)
2004 Wilhelm P. Winterstein Science Award of the German Heart Foundation
2004 Basic Science Award of the German Society for the Prevention and Rehabilitation of Cardiovascular Diseases (DGPR)
2004 Louis N. and Arnold M. Katz Price Finalist
Council on  Basic  Cardiovascular  Sciences of  the American Heart Association (AHA),
2007 W.W. Smith Charitable Trust stipend award
2009 Innovation Award of BioRegion Germany Association
2010 ADUMED Science Award, ADUMED Foundation
2013 Investors’  Choice  Award of  the Health Axis Europe/BioRN Excellence cluster competition
2015 German Society of Cardiology
Albert-Fränkel Award



Cardiac power failure treatment (WO2000/02453)

Therapeutic Window S100A1 (PCT/EP13/186913)

Muscle function enhancing peptide (PCT/EP10/002343)

Short peptides for enhancing muscle function (PCT/EP13/880705)

Tissue specific gene therapy treatment (WO2008/054713)



El-Battrawy I, Zhao Z, Lan H, Li X, Yücel G, Lang S, Sattler K, Schünemann JD, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Bieback K, Bauer R, Ratte A, Pribe-Wolferts R, Rapti K, Nowak D, Wittig J, Thomas D, Most P, Katus HA, Ravens U, Schmidt C, Borggrefe M, Zhou XB, Müller OJ, Akin I. Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy. Circ Genom Precis Med. 11(3):e001893, 2018


Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El- Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Nat Med. 1, 62-72, 2018

Müller I, Vogl T, Pappritz K, Miteva K, Savvatis K, Rohde D, Most P, Lassner D, Pieske B, Kühl U, Van Linthout S, Tschöpe C. Pathogenic Role of the Damage-Associated Molecular Patterns S100A8 and S100A9 in Coxsackievirus B3-Induced Myocarditis. Circ Heart Fail. 11, pii: e004125 2017 .

Kossack M, Hein S, Juergensen L, Siragusa M, Benz A, Katus HA, Most P*, Hassel D. Induction of  cardiac  dysfunction  in  developing  and  adult  zebrafish  by  chronic  isoproterenol stimulation. J Mol Cell Cardiol. 108, 95-105, 2017 (*co-corresponding and co-senior author)

Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW. G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. PLoS One. 12:e0182110, 2017.